In 2013-2014, Tanzania embarked on a major revamp of the management of its public health supply chains for medicines and other health supplies. These upgrades include the establishment of a national electronic logistics management information system (eLMIS) and the introduction of a Logistics Management Unit (LMU) to use the eLMIS for managing all key public health commodities. This paper describes results from the "round one" evaluation of the impact of those key management upgrades roughly one year after their introduction. The study has three main components: (1) analysis of reporting, data use, management practices, and supply chain outcomes; (2) a cost and cost-effectiveness analysis and (3) a return on investment analysis to measure savings generated by the new systems. The study used a non-experimental pre- and post-design to compare the previous system with the upgraded management system. The quantitative analysis found that stock out rates for all product goods dropped from 32% to 23%, with the frequency of stock-outs greater than 7 days dropping from 24% to 15%. Annual supply chain costs increased from $66million to $76million. Performance improved from the 2014 baseline findings of 68% to 77%, but cost per value of commodities adjusted for performance decreased from 58% at baseline to 50% in year 1.