Symbolic Finite Automata and Register Automata are two orthogonal extensions of finite automata motivated by real-world problems where data may have unbounded domains. These automata address a demand for a model over large or infinite alphabets, respectively. Both automata models have interesting applications and have been successful in their own right. In this paper, we introduce Symbolic Register Automata, a new model that combines features from both symbolic and register automata, with a view on applications that were previously out of reach. We study their properties and provide algorithms for emptiness, inclusion and equivalence checking, together with experimental results.