Cyber-physical systems (CPS) can be viewed as a new generation of systems with integrated control, communication and computational capabilities. Like the internet transformed how humans interact with one another, cyber-physical systems will transform how people interact with the physical world. Currently, the study of CPS is still in its infancy and there exist many research issues and challenges ranging from electricity power, health care, transportation and smart building etc. In this paper, an introduction of CPeSC3 (cyber physical enhanced secured wireless sensor networks (WSNs) integrated cloud computing for u-life care) architecture and its application to the health care monitoring and decision support systems is given. The proposed CPeSC3 architecture is composed of three main components, namely 1) communication core, 2) computation core, and 3) resource scheduling and management core. Detailed analysis and explanation are given for relevant models such as cloud computing, real time scheduling and security models. Finally, a medical health care application scenario is presented based on our practical test-bed which has been built for 3 years.