We introduce a new algebraic sieving technique to detect constrained multilinear monomials in multivariate polynomial generating functions given by an evaluation oracle. As applications of the technique, we show an $O^*(2^k)$-time polynomial space algorithm for the $k$-sized Graph Motif problem. We also introduce a new optimization variant of the problem, called Closest Graph Motif and solve it within the same time bound. The Closest Graph Motif problem encompasses several previously studied optimization variants, like Maximum Graph Motif, Min-Substitute Graph Motif, and Min-Add Graph Motif. Finally, we provide a piece of evidence that our result might be essentially tight: the existence of an $O^*((2-\epsilon)^k)$-time algorithm for the Graph Motif problem implies an $O((2-\epsilon')^n)$-time algorithm for Set Cover.