Using data from the Web of Science (WoS), we analyze the mutual information among university, industrial, and governmental addresses (U-I-G) at the country level for a number of countries. The dynamic evolution of the Triple Helix can thus be compared among developed and developing nations in terms of cross-sectorial co-authorship relations. The results show that the Triple-Helix interactions among the three subsystems U-I-G become less intensive over time, but unequally for different countries. We suggest that globalization erodes local Triple-Helix relations and thus can be expected to increase differentiation in national systems since the mid-1990s. This effect of globalization is more pronounced in developed countries than in developing ones. In the dynamic analysis, we focus on a more detailed comparison between China and the USA. The Chinese Academy of the (Social) Sciences changes increasingly from a public research institute to an academic one, and this has a measurable effect on China's position in the globalization.