A new solution to the curved Ewald sphere problem for 3D image reconstruction in electron microscopy

J. P. J. Chen, K. E. Schmidt, J. C. H. Spence, R. A. Kirian

We develop an algorithm capable of reconstructing 3D images of an object given a collection of two-dimensional images that are significantly influenced by the curvature of the Ewald sphere. These 2D images are not projections. Such an algorithm is useful in cryo-electron microscopy where larger samples, higher resolution, or lower energy electron beams are desired.

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