Modern data sources are typically of large scale and multi-modal natures, and acquired on irregular domains, which poses serious challenges to traditional deep learning models. These issues are partially mitigated by either extending existing deep learning algorithms to irregular domains through graphs, or by employing tensor methods to alleviate the computational bottlenecks imposed by the Curse of Dimensionality. To simultaneously resolve both these issues, we introduce a novel Multi-Graph Tensor Network (MGTN) framework, which leverages on the desirable properties of graphs, tensors and neural networks in a physically meaningful and compact manner. This equips MGTNs with the ability to exploit local information in irregular data sources at a drastically reduced parameter complexity, and over a range of learning paradigms such as regression, classification and reinforcement learning. The benefits of the MGTN framework, especially its ability to avoid overfitting through the inherent low-rank regularization properties of tensor networks, are demonstrated through its superior performance against competing models in the individual tensor, graph, and neural network domains.