Small target detection is known to be a challenging problem. Inspired by the structural characteristics and physiological mechanism of eagle-eye, a miniature vision system is designed for small target detection in this paper. First, a hardware platform is established, which consists of a pan-tilt, a short-focus camera and a long-focus camera. Then, based on the visual attention mechanism of eagle-eye, the cameras with different focal lengths are controlled cooperatively to achieve small target detection. Experimental results show that the designed biological eagle-eye vision system can accurately detect small targets, which has a strong adaptive ability.