The increasing electric power consumption and the shift towards renewable energy resources demand for new ways to operate transmission and subtransmission grids. Online Feedback Optimization (OFO) is a feedback control method that enables real-time, constrained, and optimal control of these grids. Such controllers can minimize, e.g., curtailment and losses while satisfying grid constraints like voltage and current limits. We tailor and extend the OFO control method to handle discrete inputs and explain how to design an OFO controller for the subtransmission grid. We present a novel and publicly available benchmark which is of the real French subtransmission grid on which we analyze the proposed controller in terms of robustness against model mismatch, constraint satisfaction, and tracking performance. Overall, we show that OFO controllers can help utilize the grid to its full extent, virtually reinforce it, and operate it optimally and in real-time by using flexibility offered by renewable generators connected to distribution grids.