Thermodynamic limits on general far-from-equilibrium molecular templating networks

Benjamin Qureshi, Jenny M. Poulton, Thomas E. Ouldridge

Cells produce RNA and proteins via molecular templating networks. We show that information transmission in such networks is bounded by functions of a simple thermodynamic property of the network, regardless of complexity. Surprisingly, putative systems operating at this bound do not have a high flux around the network. Instead, they have low entropy production, with each product in a ``pseudo-equilibrium'' determined by a single pathway. These pseudo-equilibrium limits constrain information transmission for the overall network, even if individual templates are arbitrarily specific.

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